Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing

Soh, J, Lin, Y, Thomas, M, Todorova, N, Kallepitis, C, Yarovsky, I, Ying, J and Stevens, M 2017, 'Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing', Advanced Functional Materials, vol. 27, no. 29, 1700523, pp. 1-9.

Document type: Journal Article
Collection: Journal Articles

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Title Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing
Author(s) Soh, J
Lin, Y
Thomas, M
Todorova, N
Kallepitis, C
Yarovsky, I
Ying, J
Stevens, M
Year 2017
Journal name Advanced Functional Materials
Volume number 27
Issue number 29
Article Number 1700523
Start page 1
End page 9
Total pages 9
Publisher Wiley-VCH Verlag
Abstract New aromatic molecule-seed particle interactions are examined and exploited to control and guide seed-mediated gold nanorod (Au NR) growth. This new approach enables better understanding of how small molecules impact the synthesis of metallic nanostructures, catalyzing their use in various biomedical applications, such as plasmonic biosensing. Experimental studies and theoretical molecular simulations using a library of aromatic molecules, making use of the chemical versatility of the molecules with varied spatial arrangements of electron-donating/withdrawing groups, charge, and Au-binding propensity, are performed. Au NR growth is regulated by two principal mechanisms, producing either a red or blue shift in the longitudinal local ized surface plasmon resonance (LLSPR) peaks. Aromatic molecules with high redox potentials produce an increase in NR aspect ratio and red shift of LLSPR peaks. In contrast, molecules that strongly bind gold surfaces result in blue shifts, demonstrating a strong correlation between their binding energy and blue shifts produced. Through enzymatic conversion of selected molecules, 4-aminophenylphosphate to 4-aminophenol, opposing growth mechanisms at opposite extremes of target concentration are obtained, and a chemical pathway for performing plasmonic enzyme-linked immunosorbent assays is established. This unlocks new strategies for tailoring substrate design and enzymatic mechanisms for controlling plasmonic response to target molecules in biosensing applications.
Subject Nanomaterials
Theory and Design of Materials
Theoretical and Computational Chemistry not elsewhere classified
Keyword(s) Alkaline phosphatase
Anisotropic growth
Aromatic additives
Gold nanorods
Plasmonic sensing
DOI - identifier 10.1002/adfm.201700523
Copyright notice © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
ISSN 1616-301X
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