Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus

Nguyen, L, Nguyen, V, Doan, V, Nguyen, V, Phan, T, Ngo, T, Do, T, Dang, T, Ho, A, Pham, X, Lenon, G, Doan, V and Hoang, V 2018, 'Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus', Diabetology & Metabolic Syndrome, vol. 10, no. 41, pp. 1-4.


Document type: Journal Article
Collection: Journal Articles

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Title Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus
Author(s) Nguyen, L
Nguyen, V
Doan, V
Nguyen, V
Phan, T
Ngo, T
Do, T
Dang, T
Ho, A
Pham, X
Lenon, G
Doan, V
Hoang, V
Year 2018
Journal name Diabetology & Metabolic Syndrome
Volume number 10
Issue number 41
Start page 1
End page 4
Total pages 4
Publisher BioMed Central
Abstract Adipokines are involved in the pathogenesis of metabolic disorders including obesity and type 2 diabetes mellitus (T2DM). This study investigates the levels of leptin, resistin, visfatin, secreted frizzled-related protein 5 (SFRP5), monocyte chemoattractant protein-1 (MCP-1) and retinol-binding protein 4 (RBP4) and their correlations with clinical parameters of overweight and T2DM. Methods: We recruited overweight 50 patients with T2DM, 88 non-overweight patients with T2DM, 29 overweight and 100 non-overweight individuals devoid of T2DM for this study. The levels of studied adipokines were measured by enzyme-linked immunosorbent assay and correlated with clinical parameters. Results: The levels of MCP-1 and SFRP5 were decreased while visfatin and RBP4 levels were increased in patients with T2DM compared to those in the control individuals (P<0.01). Among patients with T2DM, leptin and resistin levels were higher while RBP4 levels were lower in patients with overweight T2DM compared to those in patients with non overweight T2DM (P<0.0001, 0.019 and 0.05, respectively). Leptin and MCP-1 levels were correlated with HOMA-IR, QUICKI and HOMA-β. Leptin/MCP-1 ratio was correlated with insulin levels, HOMA-IR and HOMA-β indexes. Resistin/ RBP4, visfatin/MCP-1 and MCP-1/RBP4 ratios were strongly correlated with the levels of fasting glucose, HbA1c and HOMA-β. In addition, ROC curve analyses indicated a diagnostic potential of resistin/RBP4 and MCP-1/RBP4 indexes for T2DM (AUC=0.81 and 0.83, respectively) and β-cell function (AUC=0.76 and 0.74, respectively). Conclusions: Adipokines (leptin, resistin, visfatin, SFRP5, MCP-1, and RBP4) are associated with overweight and T2DM and may serve as a potential prognostic marker and therapeutic intervention for overweight-related T2DM.
Subject Metabolic Medicine
Endocrinology
Keyword(s) Type 2 diabetes mellitus
Adipokine
Overweight
Vietnam
DOI - identifier 10.1186/s13098-018-0343-4
Copyright notice © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
ISSN 1758-5996
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