The mechanical properties and in vitro biocompatibility of PM-fabricated ti-28nb-35.4zr alloy for orthopedic implant applications

Xu, W, Li, M, Wen, C, Lv, S, Liu, C, Lu, X and Qu, X 2018, 'The mechanical properties and in vitro biocompatibility of PM-fabricated ti-28nb-35.4zr alloy for orthopedic implant applications', Materials, vol. 11, no. 4, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

Title The mechanical properties and in vitro biocompatibility of PM-fabricated ti-28nb-35.4zr alloy for orthopedic implant applications
Author(s) Xu, W
Li, M
Wen, C
Lv, S
Liu, C
Lu, X
Qu, X
Year 2018
Journal name Materials
Volume number 11
Issue number 4
Start page 1
End page 13
Total pages 13
Publisher MDPI AG
Abstract A biocompatible Ti-28Nb-35.4Zr alloy used as bone implant was fabricated through the powder metallurgy process. The effects of mechanical milling and sintering temperatures on the microstructure and mechanical properties were investigated systematically, before in vitro biocompatibility of full dense Ti-28Nb-35.4Zr alloy was evaluated by cytotoxicity tests. The results show that the mechanical milling and sintering temperatures have significantly effects on the density and mechanical properties of the alloys. The relative density of the alloy fabricated by the atomized powders at 1500 °C is only 83 ± 1.8%, while the relative density of the alloy fabricated by the ball-milled powders can rapidly reach at 96.4 ± 1.3% at 1500 °C. When the temperature was increased to 1550 °C, the alloy fabricated by ball-milled powders achieve full density (relative density is 98.1 ± 1.2%). The PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C can achieve a wide range of mechanical properties, with a compressive yield strength of 1058 ± 35.1 MPa, elastic modulus of 50.8 ± 3.9 GPa, and hardness of 65.8 ± 1.5 HRA. The in vitro cytotoxicity test suggests that the PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C has no adverse effects on MC3T3-E1 cells with cytotoxicity ranking of 0 grade, which is nearly close to ELI Ti-6Al-4V or CP Ti. These properties and the net-shape manufacturability makes PM-fabricated Ti-28Nb-35.4Zr alloy a low-cost, highly-biocompatible, Ti-based biomedical alloy.
Subject Biomaterials
Metals and Alloy Materials
Keyword(s) Ball milling
Biocompatibility
Mechanical properties
Powder metallurgy
Ti-28Nb-35.4 alloy
DOI - identifier 10.3390/ma11040531
Copyright notice © 2018 by the authors.
ISSN 1996-1944
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