Pheochromocytoma (PC12) cell response on mechanobactericidal titanium surfaces

Wandiyanto, J, Linklater, D, Perera, P, Orlowska, A, Truong, V, Thissen, H, Ghanaati, S, Baulin, V, Crawford, R, Juodkazis, S and Ivanova, E 2018, 'Pheochromocytoma (PC12) cell response on mechanobactericidal titanium surfaces', Materials, vol. 11, no. 4, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

Title Pheochromocytoma (PC12) cell response on mechanobactericidal titanium surfaces
Author(s) Wandiyanto, J
Linklater, D
Perera, P
Orlowska, A
Truong, V
Thissen, H
Ghanaati, S
Baulin, V
Crawford, R
Juodkazis, S
Ivanova, E
Year 2018
Journal name Materials
Volume number 11
Issue number 4
Start page 1
End page 13
Total pages 13
Publisher MDPIAG
Abstract Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation-a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants.
Subject Physical Chemistry of Materials
Colloid and Surface Chemistry
Microbiology not elsewhere classified
Keyword(s) Mechanobactericidal surfaces
Nanostructures
PC12 cells
Titanium
DOI - identifier 10.3390/ma11040605
Copyright notice © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Creative Commons Attribution (CC BY) license.
ISSN 1996-1944
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