Characterization of 3D-printed moulds for soft lithography of millifluidic devices

Mohd Fuad, N, Mitchell, M, Kaslin, J and Wlodkowic, D 2018, 'Characterization of 3D-printed moulds for soft lithography of millifluidic devices', Micromachines, vol. 9, no. 3, pp. 1-11.

Document type: Journal Article
Collection: Journal Articles

Title Characterization of 3D-printed moulds for soft lithography of millifluidic devices
Author(s) Mohd Fuad, N
Mitchell, M
Kaslin, J
Wlodkowic, D
Year 2018
Journal name Micromachines
Volume number 9
Issue number 3
Start page 1
End page 11
Total pages 11
Publisher MDPI AG
Abstract Increased demand for inexpensive and rapid prototyping methods for micro- and millifluidic lab-on-a-chip (LOC) devices has stimulated considerable interest in alternative cost-effective fabrication techniques. Additive manufacturing (AM)-also called three-dimensional (3D) printing-provides an attractive alternative to conventional fabrication techniques. AM has been used to produce LOC master moulds from which positive replicas are made using soft-lithography and a biocompatible elastomer, poly(dimethylsiloxane) (PDMS). Here we characterize moulds made using twoAMmethods-stereolithography (SLA) and material-jetting (MJ)-and the positive replicas produced by soft lithography and PDMS moulding. The results showed that SLA, more than MJ, produced finer part resolution and finer tuning of feature geometry. Furthermore, as assessed by zebrafish (Danio rerio) biotoxicity tests, there was no toxicity observed in SLA and MJ moulded PDMS replicas. We conclude that SLA, utilizing commercially available printers and resins, combined with PDMS soft-lithography, is a simple and easily accessible technique that lends its self particularly well to the fabrication of biocompatible millifluidic devices, highly suited to the in-situ analysis of small model organisms.
Subject Manufacturing Engineering not elsewhere classified
Polymers and Plastics
Interdisciplinary Engineering not elsewhere classified
Keyword(s) Biodevices
Material jetting
Soft lithography
DOI - identifier 10.3390/mi9030116
Copyright notice © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
ISSN 2072-666X
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