Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective

Vemuri, R, Gundamaraju, R, Shastri, M, Shukla, S, Kalpurath, K, Ball, M, Tristram, S, Shankar, E, Ahuja, K and Eri, R 2018, 'Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective', BioMed Research International, vol. 2018, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

Title Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
Author(s) Vemuri, R
Gundamaraju, R
Shastri, M
Shukla, S
Kalpurath, K
Ball, M
Tristram, S
Shankar, E
Ahuja, K
Eri, R
Year 2018
Journal name BioMed Research International
Volume number 2018
Start page 1
End page 13
Total pages 13
Publisher Hindawi
Abstract Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state.
Subject Clinical Microbiology
Preventive Medicine
DOI - identifier 10.1155/2018/4178607
Copyright notice © 2018 Ravichandra Vemuri et al. Creative Commons Attribution License.
ISSN 2314-6133
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