Accelerated stem cell attachment to ultrafine grained titanium

Estrin, Y, Ivanova, E, Michalska, A, Truong, V, Lapovok, R and Boyd, R 2011, 'Accelerated stem cell attachment to ultrafine grained titanium', Acta Biomaterialia, vol. 7, no. 2, pp. 900-906.


Document type: Journal Article
Collection: Journal Articles

Title Accelerated stem cell attachment to ultrafine grained titanium
Author(s) Estrin, Y
Ivanova, E
Michalska, A
Truong, V
Lapovok, R
Boyd, R
Year 2011
Journal name Acta Biomaterialia
Volume number 7
Issue number 2
Start page 900
End page 906
Total pages 7
Publisher Elsevier BV
Abstract Commercial purity titanium with an average grain size in the low sub-micron range was produced by equal channel angular pressing (ECAP). Attachment of human bone marrow-derived mesenchymal stem cells (hMSCs) to the surface of conventional coarse grained and ECAP-modified titanium was studied. It was demonstrated that the attachment and spreading of hMSCs in the initial stages (up to 24 h) of culture was enhanced by grain refinement. Surface characterization by a range of techniques showed that the main factor responsible for the observed acceleration of hMSC attachment and spreading on titanium due to grain refinement in the bulk is the attendant changes in surface topography on the nanoscale. These results indicate that, in addition to its superior mechanical properties, ECAP-modified titanium possesses improved biocompatibility, which makes it to a potent candidate for applications in medical implants. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Subject Nanobiotechnology
Keyword(s) Cell adhesion
Cell spreading
Mesenchymal stem cell
Nanotopography
Titanium
DOI - identifier 10.1016/j.actbio.2010.09.033
Copyright notice © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
ISSN 1742-7061
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