Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering

Buividas, R, Dzingelevicius, N, Kubiliute, R, Stoddart, P, Truong, V, Ivanova, E and Juodkazis, S 2015, 'Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering', Journal of Biophotonics, vol. 8, no. 7, pp. 567-574.


Document type: Journal Article
Collection: Journal Articles

Title Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering
Author(s) Buividas, R
Dzingelevicius, N
Kubiliute, R
Stoddart, P
Truong, V
Ivanova, E
Juodkazis, S
Year 2015
Journal name Journal of Biophotonics
Volume number 8
Issue number 7
Start page 567
End page 574
Total pages 8
Publisher Wiley - V C H Verlag GmbH and Co. KGaA
Abstract Fibrillar forms of the Amyloid- (A) protein have been implicated in the early stages of Alzheimer's disease (AD), however there are no standardised assays for soluble A oligomer biomarkers that provide the best indication of the disease progression [1,2]. As a step towards a fast and label-free method for testing different AD biomarkers, we have combined laser nano-textured substrates with a SERS mapping technique and validated it using soluble A-40 oligomers [3-5]. The nano-textured SERS substrates provide fast (&5min), label-free spectra associated with soluble A-40 oligomers down to a concentration of 10 nM. Statistical analysis of the spectral intensities mapped over the substrate surface shows a quantitative correlation with the oligomer concentration.
Subject Colloid and Surface Chemistry
Keyword(s) Alzheimer's disease
Amyloid-beta
Femtosecond laser fabrication
Label-free
SERS
DOI - identifier 10.1002/jbio.201400017
Copyright notice © 2014 by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1864-063X
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