New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury

Chin, K, Chengxue, Q, May, L, Ritchie, R and Woodman, O 2017, 'New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury', Current Drug Targets, vol. 18, no. 15, pp. 1689-1711.


Document type: Journal Article
Collection: Journal Articles

Title New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury
Author(s) Chin, K
Chengxue, Q
May, L
Ritchie, R
Woodman, O
Year 2017
Journal name Current Drug Targets
Volume number 18
Issue number 15
Start page 1689
End page 1711
Total pages 23
Publisher Bentham Science Publishers Ltd.
Abstract Background: Early reperfusion of the blocked vessel is critical to restore the blood flow to the ischemic myocardium to salvage myocardial tissue and improve clinical outcome. This reperfusion strategy after a period of ischemia, however, may elicit further myocardial damage named myocardial reperfusion injury. The manifestations of reperfusion injury include arrhythmias, myocardial stunning and micro-vascular dysfunction, in addition to significant cardiomyocyte death. It is suggested that an overproduction of reactive oxygen species, intracellular calcium overload and inflammatory cell infiltration are the most important features of myocardial ischemia-reperfusion injury. Objective: In this review, various pharmacological interventions to treat myocardial reperfusion injury including the antioxidant flavonols, hydrogen sulfide, adenosine, opioids, incretin-based therapies and cyclosporin A which targets the mitochondrial permeability transition pore are discussed. Conclusion: The processes involved in reperfusion injury might provide targets for improved outcomes after myocardial infarction but thus far that aim has not been met in the clinic.
Subject Cardiology (incl. Cardiovascular Diseases)
Keyword(s) Adenosine
Antioxidant
Cardioprotection
Cyclosporin A
Flavonol
Hydrogen sulfide
Incretin-based therapies
Ischemia-reperfusion
Opioids
Reactive oxygen species
DOI - identifier 10.2174/1389450116666151001112020
Copyright notice © 2017 Bentham Science Publishers
ISSN 1389-4501
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