HIV and co-infections

Chang, C, Crane, M, Zhou, J, et al, and , 2013, 'HIV and co-infections', Immunological Reviews, vol. 254, no. 1, pp. 114-142.

Document type: Journal Article
Collection: Journal Articles

Title HIV and co-infections
Author(s) Chang, C
Crane, M
Zhou, J
et al,
Year 2013
Journal name Immunological Reviews
Volume number 254
Issue number 1
Start page 114
End page 142
Total pages 29
Publisher Wiley-Blackwell Publishing
Abstract Summary: Despite significant reductions in morbidity and mortality secondary to availability of effective combination anti-retroviral therapy (cART), human immunodeficiency virus (HIV) infection still accounts for 1.5 million deaths annually. The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high. In this review, we discuss the immunopathogenesis of five common infections that cause significant morbidity in HIV-infected patients globally. These include co-infection with Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus, hepatitis C virus, and Plasmodium falciparum. Specifically, we review the natural history of each co-infection in the setting of HIV, the specific immune defects induced by HIV, the effects of cART on the immune response to the co-infection, the pathogenesis of immune restoration disease (IRD) associated with each infection, and advances in the areas of prevention of each co-infection via vaccination. Finally, we discuss the opportunities and gaps in knowledge for future research. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Subject Infectious Diseases
Keyword(s) Cryptococcosis
Hepatitis B
Hepatitis C
Immune restoration disease
DOI - identifier 10.1111/imr.12063
ISSN 0105-2896
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