Lung stem cells: Do they exist?

Bertoncello, I and McQualter, J 2013, 'Lung stem cells: Do they exist?', Respirology, vol. 18, no. 4, pp. 587-595.


Document type: Journal Article
Collection: Journal Articles

Title Lung stem cells: Do they exist?
Author(s) Bertoncello, I
McQualter, J
Year 2013
Journal name Respirology
Volume number 18
Issue number 4
Start page 587
End page 595
Total pages 9
Publisher Wiley-Blackwell Publishing Asia
Abstract Recognition of the potential of stem cell-based therapies for alleviating intractable lung diseases has provided the impetus for research aimed at identifying regenerative cells in the adult lung, understanding how they are organized and regulated, and how they could be harnessed in lung regenerative medicine. In this review, we describe the attributes of adult stem and progenitor cells in adult organs and how they are regulated by the permissive or restrictive microenvironment in which they reside. We describe the power and limitations of experimental models, cell separative strategies and functional assays used to model the organization and regulation of adult airway and alveolar stem cells in the adult lung. The review summarizes recent progress and obstacles in defining endogenous lung epithelial stem and progenitor cells in mouse models and in translational studies.
Subject Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Keyword(s) adult stem cell
airway epithelium
animal model
cell biology
lung regeneration
DOI - identifier 10.1111/resp.12073
Copyright notice © 2013 Asian Pacific Society of Respirology
ISSN 1323-7799
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