Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of ageing respectively

Angelovich, T, Hearps, A, Maisa, A, Martin, G, Lichtfuss, G, Cheng, W, Palmer, C, Landay, A, Crowe, S and Jaworowski, A 2015, 'Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of ageing respectively', Journal of Acquired Immune Deficiency Syndromes, vol. 69, no. 1, pp. 11-17.


Document type: Journal Article
Collection: Journal Articles

Title Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of ageing respectively
Author(s) Angelovich, T
Hearps, A
Maisa, A
Martin, G
Lichtfuss, G
Cheng, W
Palmer, C
Landay, A
Crowe, S
Jaworowski, A
Year 2015
Journal name Journal of Acquired Immune Deficiency Syndromes
Volume number 69
Issue number 1
Start page 11
End page 17
Total pages 7
Publisher Lippincott Williams and Wilkins
Abstract Background: Chronic inflammation and immune activation occur in both HIV infection and normal aging and are associated with inflammatory disease. However, the degree to which HIV influences age-related innate immune changes, and the biomarkers which best reflect them, remains unclear. Methods and Results: We measured established innate immune aging biomarkers in 309 individuals including 88 virologically suppressed (VS) and 52 viremic (viral load ≤ and >50 copies per milliliter, respectively) HIV-positive individuals. Levels of soluble (ie, CXCL10, soluble CD163, neopterin) and cellular (ie, proportions of inflammatory CD16 + monocytes) biomarkers of monocyte activation were increased in HIV-positive individuals and were only partially ameliorated by viral suppression. Viremic and VS HIV-positive individuals show levels of age-related monocyte activation biomarkers that are similar to uninfected controls aged 12 and 4 years older, respectively. Viremic HIV infection was associated with an accelerated rate of change of some monocyte activation markers (eg, neopterin) with age, whereas in VS individuals, subsequent age-related changes occurred at a similar rate as in controls, albeit at a higher absolute level. We further identified CXCL10 as a robust soluble biomarker of monocyte activation, highlighting the potential utility of this chemokine as a prognostic marker. Implications: These findings may partially explain the increased prevalence of inflammatory age-related diseases in HIV-positive individuals and potentially indicate the pathological mechanisms underlying these diseases, which persist despite viral suppression.
Subject Infectious Diseases
Geriatrics and Gerontology
Innate Immunity
Keyword(s) aging
HIV
innate immune activation
monocyte
DOI - identifier 10.1097/QAI.0000000000000559
Copyright notice © 2015 Wolters Kluwer Health, Inc.
ISSN 1525-4135
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