Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination

Noho-Konteh, F, Adetifa, J, Cox, M and Plebanski, M 2016, 'Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination', Clinical Infectious Diseases, vol. 63, no. 9, pp. 1213-1226.


Document type: Journal Article
Collection: Journal Articles

Title Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination
Author(s) Noho-Konteh, F
Adetifa, J
Cox, M
Plebanski, M
Year 2016
Journal name Clinical Infectious Diseases
Volume number 63
Issue number 9
Start page 1213
End page 1226
Total pages 14
Publisher Oxford University Press
Abstract Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking. This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.
Subject Immunology not elsewhere classified
Keyword(s) Cytokines
Heterologous effects
Innate immunity
T cells
Transcriptome
DOI - identifier 10.1093/cid/ciw492
Copyright notice © The Author 2016.
ISSN 1058-4838
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