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Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation Kong, Y, Fuchsberger, M, Plebanski, M and Apostolopoulos, V 2016, 'Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation', Acta Biochimica et Biophysica Sinica, vol. 48, no. 12, pp. 1101-1111. Document type: Journal Article Collection: Journal Articles Title Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation Author(s) Kong, Y Fuchsberger, M Plebanski, M Apostolopoulos, V Year 2016 Journal name Acta Biochimica et Biophysica Sinica Volume number 48 Issue number 12 Start page 1101 End page 1111 Total pages 11 Publisher Oxford University Press Abstract Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer immunotherapy studies. However, we demonstrate that cancer cell lines can negatively interfere with DC generation in granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived cultures, although cancer cells are able to enhance CD80 cell surface activation marker and cytokine secretion. Furthermore, in the presence of cancer cells, GM-CSF-derived DCs are unable to stimulate T-cells. Additional stimulation with toll-like receptor 4 cannot fully reverse the suppressive effect of cancer cells or supernatant. Hence, it is imperative to understand the immunosuppressive effects of cancer on DCs in order for DC-based cancer immunotherapy to be successful. Subject Immunology not elsewhere classified Keyword(s) Cytokines Dendritic cells Early dendritic cells GM-CSF DOI - identifier 10.1093/abbs/gmw102 Copyright notice © The Author 2016. All rights reserved. ISSN 1672-9145 Related Links Link Description https://dx.doi.org/10.1093/abbs/gmw102 Link to Published Version   Versions Version Filter Type Mon, 10 Dec 2018, 13:22:02 EST Fri, 09 Aug 2019, 14:27:39 EST Filtered Full Citation counts:   Cited 1 times in Thomson Reuters Web of Science Article | Citations Cited 0 times in Scopus Article Altmetric details: Access Statistics: 5 Abstract Views  -  Detailed Statistics Created: Thu, 06 Dec 2018, 10:39:00 EST by Catalyst Administrator