Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation

Kong, Y, Fuchsberger, M, Plebanski, M and Apostolopoulos, V 2016, 'Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation', Acta Biochimica et Biophysica Sinica, vol. 48, no. 12, pp. 1101-1111.


Document type: Journal Article
Collection: Journal Articles

Title Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation
Author(s) Kong, Y
Fuchsberger, M
Plebanski, M
Apostolopoulos, V
Year 2016
Journal name Acta Biochimica et Biophysica Sinica
Volume number 48
Issue number 12
Start page 1101
End page 1111
Total pages 11
Publisher Oxford University Press
Abstract Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer immunotherapy studies. However, we demonstrate that cancer cell lines can negatively interfere with DC generation in granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived cultures, although cancer cells are able to enhance CD80 cell surface activation marker and cytokine secretion. Furthermore, in the presence of cancer cells, GM-CSF-derived DCs are unable to stimulate T-cells. Additional stimulation with toll-like receptor 4 cannot fully reverse the suppressive effect of cancer cells or supernatant. Hence, it is imperative to understand the immunosuppressive effects of cancer on DCs in order for DC-based cancer immunotherapy to be successful.
Subject Immunology not elsewhere classified
Keyword(s) Cytokines
Dendritic cells
Early dendritic cells
GM-CSF
DOI - identifier 10.1093/abbs/gmw102
Copyright notice © The Author 2016. All rights reserved.
ISSN 1672-9145
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