Low dose cyclophosphamide: Mechanisms of T cell modulation

Madondo, M, Quinn, M and Plebanski, M 2016, 'Low dose cyclophosphamide: Mechanisms of T cell modulation', Cancer Treatment Reviews, vol. 42, pp. 3-9.


Document type: Journal Article
Collection: Journal Articles

Title Low dose cyclophosphamide: Mechanisms of T cell modulation
Author(s) Madondo, M
Quinn, M
Plebanski, M
Year 2016
Journal name Cancer Treatment Reviews
Volume number 42
Start page 3
End page 9
Total pages 7
Publisher W.B. Saunders Co. Ltd.
Abstract © 2015 Published by Elsevier Ltd. Cyclophosphamide is considered one of the most successful chemotherapy drugs and is listed on the World Health Organisations List of Essential Medicines. Since its initial synthesis in 1958, it has been widely used to treat a range of cancers but its use has been declining due to the advent of platinum based and other chemotherapy agents. However, cyclophosphamide is still used either as a single agent or as adjuvant therapy to treat lymphomas, and breast and ovarian cancers at much lower doses. The efficacy of low dose cyclophosphamide is primarily due to its ability to promote anti-tumour immunity, by selectively depleting regulatory T cells and enhancing effector T cell function. Compared to effecter T cells, regulatory T cells have metabolic adaptations that make them more susceptible to cyclophosphamide-mediated cytotoxicity. In this review, we highlight the potential for improving the efficacy of low dose cyclophosphamide by combining insights on the mechanisms of cyclophosphamide-mediated cytotoxicity, and how these cytotoxic effects of cyclophosphamide influence T cell function, thereby contributing to anti-tumour immunity.
Subject Immunology not elsewhere classified
Keyword(s) Acrolein
Chemotherapy
Cyclophosphamide
GSH
T cells
DOI - identifier 10.1016/j.ctrv.2015.11.005
Copyright notice © 2015 Published by Elsevier Ltd.
ISSN 0305-7372
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