The effects of engineered nanoparticles on pulmonary immune homeostasis

Mohamud, R, Xiang, S, Selomulya, C, Rolland, J, O'Hehir, R, Hardy, C and Plebanski, M 2014, 'The effects of engineered nanoparticles on pulmonary immune homeostasis', Drug Metabolism Reviews, vol. 46, no. 2, pp. 176-190.


Document type: Journal Article
Collection: Journal Articles

Title The effects of engineered nanoparticles on pulmonary immune homeostasis
Author(s) Mohamud, R
Xiang, S
Selomulya, C
Rolland, J
O'Hehir, R
Hardy, C
Plebanski, M
Year 2014
Journal name Drug Metabolism Reviews
Volume number 46
Issue number 2
Start page 176
End page 190
Total pages 15
Publisher Taylor & Francis Inc.
Abstract Engineered nanoparticles (ENP), which could be composed of inorganic metals, metal oxides, metalloids, organic biodegradable and inorganic biocompatible polymers, are being used as carriers for vaccine and drug delivery. There is also increasing interest in their application as delivery agents for the treatment of a variety of lung diseases. Although many studies have shown ENP can be effectively and safely used to enhance the delivery of drugs and vaccines in the periphery, there is concern that some ENP could promote inflammation, with unknown consequences for lung immune homeostasis. In this study, we review research on the effects of ENP on lung immunity, focusing on recent studies using diverse animal models of human lung disease. We summarize how the inflammatory and immune response to ENP is influenced by the diverse biophysical and chemical characteristics of the particles including composition, size and mode of delivery. We further discuss newly described unexpected beneficial properties of ENP administered into the lung, where biocompatible polystyrene or silver nanoparticles can by themselves decrease susceptibility to allergic airways inflammation. Increasing our understanding of the differential effects of diverse types of nanoparticles on pulmonary immune homeostasis, particularly previously underappreciated beneficial outcomes, supports rational ENP translation into novel therapeutics for prevention and/or treatment of inflammatory lung disorders.
Subject Immunology not elsewhere classified
Keyword(s) Animal models
Delivery vehicles
Immune response
Inflammation
Lung
Particles
Toxicity
Vaccine
DOI - identifier 10.3109/03602532.2013.859688
Copyright notice © 2014 Informa Healthcare USA, Inc.
ISSN 0360-2532
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