CD38 identifies a hypo-proliferative IL-13-secreting CD4(+) T-cell subset that does not fit into existing naive and memory phenotype paradigms

Plebanski, M 2011, 'CD38 identifies a hypo-proliferative IL-13-secreting CD4(+) T-cell subset that does not fit into existing naive and memory phenotype paradigms', European Journal of Immunology, vol. 41, no. 5, pp. 1298-1308.


Document type: Journal Article
Collection: Journal Articles

Title CD38 identifies a hypo-proliferative IL-13-secreting CD4(+) T-cell subset that does not fit into existing naive and memory phenotype paradigms
Author(s) Plebanski, M
Year 2011
Journal name European Journal of Immunology
Volume number 41
Issue number 5
Start page 1298
End page 1308
Total pages 11
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract CD38 is commonly regarded as an activation marker for human T cells. Herein, we show that CD38 expression identifies a hypo-proliferative CD4+ T-cell subset that, following TCR stimulation, retains expression of naive cell surface markers including CD45RA, CD62L and CCR7. Hypo-proliferation was mediated by reduced CD25 up-regulation upon TCR stimulation compared to CD4+CD38- cells and lack of responsiveness to exogenous IL-2. Instead, CD4+CD38+ T cells expressed CD127, and hypo-proliferation was reversed by addition of IL-7, further associated with increased STAT5 phosphorylation. This phenotype was exacerbated by addition of an agonistic CD38-binding antibody, suggesting that signaling through CD38 promotes this cell profile. Activated CD4+CD38+ cells had a bias towards IL-13 secretion, but not other Th2 cytokines such as IL-4 or IL-5. In comparison, the CD4+CD38- cells had a clear bias towards secretion of Th1-associated cytokines IFN-γ and TNF. The existence of such CD4+CD38+ T cells may play an important role in pathologies such as asthma, which are associated with IL-13, but not IL-4 and IL-5. Coupled with responsiveness to IL-7 but not IL-2, and the involvement of CD38 ligation, our results highlight a unique T-cell subpopulation that does not fit into existing naive and memory cell paradigms.
Subject Immunology not elsewhere classified
Keyword(s) CD4 T cells
Cell surface molecules
Cellular activation
DOI - identifier 10.1002/eji.201040726
Copyright notice © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISSN 0014-2980
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