Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria

Armistead, J, Morlais, I, Mathias, D, Jardim, J and Plebanski, M 2014, 'Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria', Infection and Immunity, vol. 82, no. 2, pp. 818-829.


Document type: Journal Article
Collection: Journal Articles

Title Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria
Author(s) Armistead, J
Morlais, I
Mathias, D
Jardim, J
Plebanski, M
Year 2014
Journal name Infection and Immunity
Volume number 82
Issue number 2
Start page 818
End page 829
Total pages 12
Publisher American Society for Microbiology
Abstract Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrated that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in countries to which malaria is endemic. Using a biochemical and immunological approach, we determined that the mechanism of action for this phenomenon stems from antibody recognition of a single protective epitope on AnAPN1, which we found to be immunogenic in murine and nonhuman primate models and highly conserved among anophelines. These data indicate that AnAPN1 meets the established target product profile for TBVs and suggest a potential key role for an AnAPN1-based panmalaria TBV in the effort to eradicate malaria.
Subject Immunology not elsewhere classified
DOI - identifier 10.1128/IAI.01222-13
Copyright notice © 2014, American Society for Microbiology.
ISSN 0019-9567
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