Heterologous and sex differential effects of administering vitamin A supplementation with vaccines

Jensen, K, Ndure, J, Plebanski, M and Flanagan, K 2014, 'Heterologous and sex differential effects of administering vitamin A supplementation with vaccines', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 109, no. 1, pp. 36-45.


Document type: Journal Article
Collection: Journal Articles

Title Heterologous and sex differential effects of administering vitamin A supplementation with vaccines
Author(s) Jensen, K
Ndure, J
Plebanski, M
Flanagan, K
Year 2014
Journal name Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume number 109
Issue number 1
Start page 36
End page 45
Total pages 10
Publisher Oxford University Press
Abstract WHO recommends high-dose vitamin A supplementation (VAS) to children from 6 months to 5 years of age in low-income countries, in order to prevent and treat vitamin A deficiency-associated morbidity and mortality. The current policy does not discriminate this recommendation either by sex or vaccination status of the child. There is accumulating evidence that the effects of VAS on morbidity, mortality and immunological parameters depend on concomitant vaccination status. Moreover, these interactions may manifest differently in males and females. Certain vaccines administered through the Expanded Program on Immunization have been shown to alter all-cause mortality from infections other than the vaccine-targeted disease. This review summarizes the evidence from observational studies and randomized-controlled trials of the effects of VAS on these so-called heterologous or non-specific effects of vaccines, with a focus on sex differences. In general, VAS seems to enhance the heterologous effects of vaccines, particularly for diphtheria-tetanus-pertussis and live measles vaccines, where some studies, although not unanimously, show a stronger interaction between VAS and vaccination in females.We suggest that vaccination status and sex should be considered when evaluating the effects of VAS in early life.
Subject Immunology not elsewhere classified
Keyword(s) All-cause mortality
BCG vaccine
DTP vaccine
Measles vaccine
Sex
Vitamin A
DOI - identifier 10.1093/trstmh/tru184
Copyright notice © The Author 2014.
ISSN 0035-9203
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