Effect of Vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: A randomized placebo-controlled trial

Mousa, A, Naderpoor, N, Johnson, J, Sourris, K, de Courten, M, Wilson, K, Scragg, R, Plebanski, M and de Courten, B 2017, 'Effect of Vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: A randomized placebo-controlled trial', Scientific Reports, vol. 7, no. 1, pp. 1-1.


Document type: Journal Article
Collection: Journal Articles

Title Effect of Vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: A randomized placebo-controlled trial
Author(s) Mousa, A
Naderpoor, N
Johnson, J
Sourris, K
de Courten, M
Wilson, K
Scragg, R
Plebanski, M
de Courten, B
Year 2017
Journal name Scientific Reports
Volume number 7
Issue number 1
Start page 1
End page 1
Total pages 1
Publisher Nature
Abstract In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NF kappa B) activity. Yet, no trials have examined the effects of vitamin D supplementation on NF kappa B activity in-vivo in humans. We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NF kappa B activity in peripheral blood mononuclear cells (PBMCs). Sixty-five overweight/obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH) D] <= 50 nmol/L) adults were randomized to a single 100,000 IU bolus followed by 4,000 IU daily cholecalciferol or matching placebo for 16 weeks. We measured BMI, % body fat, serum 25(OH) D, high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor (TNF), monocyte chemoattractant protein-1 (MCP-1), interferon-gamma (IFN-gamma), several interleukins, and NF kappa B activity in PBMCs. Fifty-four participants completed the study. Serum 25(OH) D concentrations increased with vitamin D supplementation compared to placebo (p < 0.001). Vitamin D and placebo groups did not differ in any inflammatory markers or NF kappa B activity (all p > 0.05). Results remained non-significant after adjustment for age, sex, and % body fat, and after further adjustment for sun exposure, physical activity, and dietary vitamin D intake. Although in-vitro studies report anti-inflammatory effects of vitamin D, our RCT data show no effect of vitamin D supplementation on inflammatory markers or NF kappa B activity in-vivo in humans.
Subject Immunology not elsewhere classified
Keyword(s) D Deficiency
Insulin-Resistance
Pancreatic-Islets
Obese Subjects
Dna-Binding
Cell Lines
In-Vitro
Markers
Metaanalysis
1
25-Dihydroxyvitamin-D3
DOI - identifier 10.1038/s41598-017-15264-1
Copyright notice © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License
ISSN 2045-2322
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