Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not DiphtheriaTetanusPertussis Vaccine Implies a Regulatory Role2 

Plebanski, M 2017, 'Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not DiphtheriaTetanusPertussis Vaccine Implies a Regulatory Role2 ', Frontiers in Immunology, vol. 8, no. AUG, pp. 1-12.


Document type: Journal Article
Collection: Journal Articles

Title Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not DiphtheriaTetanusPertussis Vaccine Implies a Regulatory Role2 
Author(s) Plebanski, M
Year 2017
Journal name Frontiers in Immunology
Volume number 8
Issue number AUG
Start page 1
End page 12
Total pages 12
Publisher Frontiers Research Foundation
Abstract Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to target Tregs. Infants have high numbers of Tregs and often have poor responses to vaccination, yet the role Tregs play in controlling vaccine immunogenicity has not been explored in this age group. Herein, we explore the role of CD4+FOXP3+CD127− Tregs in controlling immunity in infant males and females to vaccination with diphtheriatetanuswhole cell pertussis (DTP) and/or measles vaccine (MV). We find correlative evidence that circulating Tregs at the time of vaccination suppress antibody responses to MV but not DTP; and Tregs 4 weeks after DTP vaccination may suppress vaccine-specific cellular immunity. This opens the exciting possibility that Tregs may provide a future target for improved vaccine responses in early life, including reducing the number of doses of vaccine required. Such an approach would need to be safe and the benefits outweigh the risks, thus further research in this area is required.
Subject Immunology not elsewhere classified
Keyword(s) Antibodies
Beta-2 microglobulin
Cytokines
Immune activation
Regulatory T cells
Sex
Vaccines
DOI - identifier 10.3389/fimmu.2017.00921
Copyright notice © 2017 Ndure, Noho-Konteh, Adetifa, Cox, Barker, Le, Sanyang, Drammeh, Whittle, Clarke, Plebanski, Rowland-Jones and Flanagan.
ISSN 1664-3224
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