TNFR2 expression on CD25(hi)FOXP3(+) T cells induced upon TCR stimulation of CD4T cells identifies maximal cytokine-producing effectors 

Govindaraj, C, Scalzo-Inguanti, K, Scholzen, A, Li, S and Plebanski, M 2013, 'TNFR2 expression on CD25(hi)FOXP3(+) T cells induced upon TCR stimulation of CD4T cells identifies maximal cytokine-producing effectors ', Frontiers in Immunology, vol. 4, no. AUG, UNSP 233, pp. 1-1.


Document type: Journal Article
Collection: Journal Articles

Title TNFR2 expression on CD25(hi)FOXP3(+) T cells induced upon TCR stimulation of CD4T cells identifies maximal cytokine-producing effectors 
Author(s) Govindaraj, C
Scalzo-Inguanti, K
Scholzen, A
Li, S
Plebanski, M
Year 2013
Journal name Frontiers in Immunology
Volume number 4
Issue number AUG
Article Number UNSP 233
Start page 1
End page 1
Total pages 1
Publisher Frontiers Research Foundation
Abstract In this study, we show that CD25hiTNFR2+ cells can be rapidly generated in vitro from circulating CD4 lymphocytes by polyclonal stimuli anti-CD3 in the presence of anti-CD28. The in vitro induced CD25hiTNFR2+ T cells express a conventional regulatory T cells phenotype FOXP3+CTLA4+CD127lo/−, but produce effector and immunoregulatory cytokines including IL-2, IL-10, and IFN-g. These induced CD25hiTNFR2+ T cells do not suppress target cell proliferation, but enhance it instead. Thus the CD25hiTNFR2+ phenotype induced rapidly following CD3/28 cross linking of CD4 T cells identifies cells with maximal proliferative and effector cytokine-producing capability. The in vivo counterpart of this cell population may play an important role in immune response initiation.
Subject Immunology not elsewhere classified
Keyword(s) Effector cells
Foxp3
Regulatory T cells
Th1
Tnfr2
DOI - identifier 10.3389/fimmu.2013.00233
Copyright notice © 2013 Govindaraj, Scalzo-Inguanti, Scholzen, Li and Plebanski.
ISSN 1664-3224
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