Immunological effects among workers who handle engineered nanoparticles

Plebanski, M 2017, 'Immunological effects among workers who handle engineered nanoparticles', Occupational and Environmental Medicine, vol. 74, no. 12, pp. 868-876.


Document type: Journal Article
Collection: Journal Articles

Title Immunological effects among workers who handle engineered nanoparticles
Author(s) Plebanski, M
Year 2017
Journal name Occupational and Environmental Medicine
Volume number 74
Issue number 12
Start page 868
End page 876
Total pages 9
Publisher B M J Group
Abstract Objective To determine whether exposure of workers handling engineered nanoparticles (ENPs) may result in increased inflammation and changes in lung function. Methods A prospective panel study compared changes in several markers of inflammation for ENP handling and non-ENP handling control workers. Nanoparticle exposure was measured during ENP handling and for controls. Lung function, fraction of exhaled nitric oxide (FeNO), C-reactive protein (CRP), blood cell counts and several serum cytokines were measured at baseline, at the end of the shift and at the end of the working week. Results Nanoparticle exposure was not higher when ENPs were being handled; nanoparticle counts were higher in offices and in ambient air than in laboratories. There were no differences at baseline in lung function, FeNO, haemoglobin, platelet, white cell counts or CRP levels between those who handled nanoparticles and those who did not, with or without asthmatic participants. There were statistically significant increases in sCD40 and sTNFR2 over the working day for those who handled ENPs. The changes were larger and statistically significant over the working week and sCD62P also showed a statistically significant difference. The changes were slightly smaller and less likely to be statistically significant for atopic than for non-atopic participants. Conclusions Even at low ENP exposure, increases in three cytokines were significant over the week for those who handled nanoparticles, compared with those who did not. However, exposure to low and transient levels of nanoparticles was insufficient, to trigger measurable changes in spirometry, FeNO, CRP or blood cell counts.
Subject Immunology not elsewhere classified
Keyword(s) blood
engineered nanoparticles
immune markers
spirometry
DOI - identifier 10.1136/oemed-2016-104111
Copyright notice © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
ISSN 1351-0711
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