Polymorphism in liver-stage malaria vaccine candidate proteins: Immune evasion and implications for vaccine design

Plebanski, M, Flanagan, K and Wilson, K 2016, 'Polymorphism in liver-stage malaria vaccine candidate proteins: Immune evasion and implications for vaccine design', Expert Review of Vaccines, vol. 15, no. 3, pp. 389-399.


Document type: Journal Article
Collection: Journal Articles

Title Polymorphism in liver-stage malaria vaccine candidate proteins: Immune evasion and implications for vaccine design
Author(s) Plebanski, M
Flanagan, K
Wilson, K
Year 2016
Journal name Expert Review of Vaccines
Volume number 15
Issue number 3
Start page 389
End page 399
Total pages 11
Publisher Taylor & Francis
Abstract © 2015 Taylor & Francis. The pre-erythrocytic stage of infection by malaria parasites represents a key target for vaccines that aim to eradicate malaria. Two important broad immune evasion strategies that can interfere with vaccine efficacy include the induction of dendritic cell (DC) dysfunction and regulatory T cells (Tregs) by blood-stage malaria parasites, leading to inefficient priming of T cells targeting liver-stage infections. The parasite also uses surgical strike strategies, whereby polymorphism in pre-erythrocytic antigens can interfere with host immunity. Specifically, we review how even single amino acid changes in T cell epitopes can lead to loss of binding to major histocompatibility complex (MHC), lack of cross-reactivity, or antagonism and immune interference, where simultaneous or sequential stimulation with related variants of the same T cell epitope can cause T cell anergy or the conversion of effector to immunosuppressive T cell phenotypes.
Subject Immunology not elsewhere classified
Keyword(s) Antagonism
Antigen
Cross-reactivity
Immune evasion
Immune interference
Malaria
Polymorphism
Pre-erythrocytic
Vaccine
DOI - identifier 10.1586/14760584.2016.1125785
Copyright notice © 2015 Taylor & Francis.
ISSN 1476-0584
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