Myeloid derived suppressor cells and their role in diseases

Kong, Y, Fuchsberger, M, Xiang, S, Apostolopoulos, V and Plebanski, M 2013, 'Myeloid derived suppressor cells and their role in diseases', Current Medicinal Chemistry, vol. 20, no. 11, pp. 1437-1444.


Document type: Journal Article
Collection: Journal Articles

Title Myeloid derived suppressor cells and their role in diseases
Author(s) Kong, Y
Fuchsberger, M
Xiang, S
Apostolopoulos, V
Plebanski, M
Year 2013
Journal name Current Medicinal Chemistry
Volume number 20
Issue number 11
Start page 1437
End page 1444
Total pages 8
Publisher Bentham Science Publishers Ltd.
Abstract Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitors that can play a major role in tumour development and chronic inflammation. The importance of the suppressive function of MDSCs was first suggested by studies involving cancer patients and cancer-bearing mice. In addition, recent studies have demonstrated that MDSCs can also be involved in many other pathological conditions. MDSCs have unique ways of abrogating an immune response in addition to those utilised by other immune-suppressive cell types, for example via the induction of arginase-1 and consequent upregulation in reactive oxygen species (ROS) production. Due to their heterogeneity, they further can express a variety of lineage markers, which overlap with other myeloid cell types such as Gr1, CD11b, MHCIIlo, Ly6C and Ly6G, making it difficult to identify them by surface phenotype alone. The disparity between mouse and human MDSCs further complicates the identification of these elusive cell populations. In this review, we will summarise the recent updates on the methods for eliciting and studying different MDSC subsets, including newly proposed surface phenotypes, as well as insights into how their function is being characterised in both mice and humans. In addition, exciting new discoveries suggesting their involvement across a number of different pathological settings, such as sepsis, autoimmunity and Leishmaniasis, will be discussed.
Subject Immunology not elsewhere classified
Keyword(s) Arginase-1
Chronic Inflammation
Dendritic Cells (Dcs)
Granulocytes
Immune Response
Inducible Nitric Oxide Synthase (Inos)
Monocytes
Myeloid derived suppressor cells (MDSCs)
Reactive Oxygen Species (Ros)
Suppression
Tumour Development
DOI - identifier 10.2174/0929867311320110006
Copyright notice © 2013 Bentham Science Publishers.
ISSN 0929-8673
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