Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents

Chakraborty, A, Boer, J, Selomulya, C and Plebanski, M 2018, 'Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents', Bioconjugate Chemistry, vol. 29, no. 3, pp. 657-671.

Document type: Journal Article
Collection: Journal Articles

Title Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents
Author(s) Chakraborty, A
Boer, J
Selomulya, C
Plebanski, M
Year 2018
Journal name Bioconjugate Chemistry
Volume number 29
Issue number 3
Start page 657
End page 671
Total pages 15
Publisher American Chemical Society
Abstract The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nano particles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation, and instability in some biological environments limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery, and in vivo imaging. Coating with amino acids, rather than peptides, offers further a highly cost-effective approach (due to their ease of purification and availability), but is currently an underutilized way to decrease toxicity and enhance stability. Amino acid molecules are small (< 200 Da) and have both positive and negative charge groups (zwitterionic) facilitating charge-specific molecule binding. Additionally, amino acids exert by themselves some useful biological functions, with antibacterial and viability enhancing properties (for eukaryotic cells). Overall particle size, nanoparticle core, and the specific amino acid used to functionalize their surface influence their biodistribution, and their effects on host immunity. In this review, we provide for the first time an overview of this emerging field, and identify gaps in knowledge for future research.
Subject Immunology not elsewhere classified
Keyword(s) Iron-Oxide Nanoparticles
Allergic Airway Inflammation
On Fluorescent Biosensor
Walled Carbon Nanotubes
Gold Nanoparticles
Cellular Uptake
Silver Nanoparticles
Magnetic Nanoparticles
Antibacterial Activity
DOI - identifier 10.1021/acs.bioconjchem.7b00455
Copyright notice © 2017 American Chemical Society
ISSN 1043-1802
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