Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

Daillere, R, Vetizou, M, Waldschmitt, N and Plebanski, M 2016, 'Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects', Immunity, vol. 45, no. 4, pp. 931-943.


Document type: Journal Article
Collection: Journal Articles

Title Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Author(s) Daillere, R
Vetizou, M
Waldschmitt, N
Plebanski, M
Year 2016
Journal name Immunity
Volume number 45
Issue number 4
Start page 931
End page 943
Total pages 13
Publisher Cell Press
Abstract The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-γ-producing γδT cells in cancer lesions. The immune sensor, NOD2, limited CTX-induced cancer immunosurveillance and the bioactivity of these microbes. Finally, E. hirae and B. intestinihominis specific-memory Th1 cell immune responses selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy. Altogether, E. hirae and B. intestinihominis represent valuable oncomicrobiotics ameliorating the efficacy of the most common alkylating immunomodulatory compound.
Subject Immunology not elsewhere classified
DOI - identifier 10.1016/j.immuni.2016.09.009
Copyright notice © 2016 Elsevier Inc
ISSN 1074-7613
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