Sex and gender differences in the outcomes of vaccination over the life course

Fink, A, Plebanski, M, Flanagan, K and Klein, S 2017, 'Sex and gender differences in the outcomes of vaccination over the life course', Annual Review of Cell and Developmental Biology, vol. 33, pp. 577-599.


Document type: Journal Article
Collection: Journal Articles

Title Sex and gender differences in the outcomes of vaccination over the life course
Author(s) Fink, A
Plebanski, M
Flanagan, K
Klein, S
Year 2017
Journal name Annual Review of Cell and Developmental Biology
Volume number 33
Start page 577
End page 599
Total pages 23
Publisher Annual Reviews
Abstract Both sex (i.e., biological differences) and gender (i.e., social or cultural influences) impact vaccine acceptance, responses, and outcomes. Clinical data illustrate that among children, young adults, and aged individuals, males and females differ in vaccine-induced immune responses, adverse events, and protection. Although males are more likely to receive vaccines, following vaccination, females typically develop higher antibody responses and report more adverse effects of vaccination than do males. Human, nonhuman animal, and in vitro studies reveal numerous immunological, genetic, hormonal, and environmental factors that differ between males and females and contribute to sex- and gender-specific vaccine responses and outcomes. Herein, we address the impact of sex and gender variables that should be considered in preclinical and clinical studies of vaccines.
Subject Immunology not elsewhere classified
Keyword(s) Adverse reaction
Antibody response
Microbiome
Sex chromosomes
Sex steroids
Vaccine acceptance
Vaccine efficacy
DOI - identifier 10.1146/annurev-cellbio-100616-060718
Copyright notice © Copyright 2017 by Annual Reviews. All rights reserved.
ISSN 1081-0706
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