Cardiovascular risk of adipokines: a review

Dutheil, F, Gordon, B, Naughton, G, Crendal, E, Courteix, D, Chaplais, E, Thivel, D, Lac, G and Benson, A 2018, 'Cardiovascular risk of adipokines: a review', Journal of International Medical Research, vol. 46, no. 6, pp. 2082-2095.


Document type: Journal Article
Collection: Journal Articles

Title Cardiovascular risk of adipokines: a review
Author(s) Dutheil, F
Gordon, B
Naughton, G
Crendal, E
Courteix, D
Chaplais, E
Thivel, D
Lac, G
Benson, A
Year 2018
Journal name Journal of International Medical Research
Volume number 46
Issue number 6
Start page 2082
End page 2095
Total pages 14
Publisher Sage
Abstract Over the last two decades, the understanding of adipose tissue has undergone radical change. The perception has evolved from an inert energy storage tissue to that of an active endocrine organ. Adipose tissue releases a cluster of active molecules named adipokines. The severity of obesity-related diseases does not necessarily correlate with the extent of body fat accumulation but is closely related to body fat distribution, particularly to visceral localization. There is a distinction between the metabolic function of central obesity (visceral abdominal) and peripheral obesity (subcutaneous) in the production of adipokines. Visceral fat accumulation, linked with levels of some adipokines, induces chronic inflammation and metabolic disorders, including glucose intolerance, hyperlipidaemia, and arterial hypertension. Together, these conditions contribute to a diagnosis of metabolic syndrome, directly associated with the onset of cardiovascular disease. If it is well known that adipokines contribute to the inflammatory profile and appetite regulation, this review is novel in synthesising the current state of knowledge of the role of visceral adipose tissue and its secretion of adipokines in cardiovascular risk.
Subject Cardiovascular Medicine and Haematology not elsewhere classified
Keyword(s) adipokines
appetite
cardiovascular disease
central obesity
inflammation
Metabolic syndrome
visceral adipose tissue
DOI - identifier 10.1177/0300060517706578
Copyright notice © The Author(s) 2017 Creative Commons CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License
ISSN 0300-0605
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