Prospects of optical biosensors for emerging label-free RNA analysis

Carrascosa, L, Sanchez Huertas, C and Lechuga, L 2016, 'Prospects of optical biosensors for emerging label-free RNA analysis', Trends in Analytical Chemistry, vol. 80, pp. 177-189.


Document type: Journal Article
Collection: Journal Articles

Title Prospects of optical biosensors for emerging label-free RNA analysis
Author(s) Carrascosa, L
Sanchez Huertas, C
Lechuga, L
Year 2016
Journal name Trends in Analytical Chemistry
Volume number 80
Start page 177
End page 189
Total pages 13
Publisher Elsevier BV
Abstract RNA is critical in countless cellular processes, and researchers are constantly discovering new types and attributing them different roles. Consequently, a growing interest in efficient RNA analysis has arisen. However, RNA detection is complicated and generally requires the use of labels. Major efforts are being devoted to conceive new approaches for RNA analysis with no need of markers. Optical biosensing is a highly sensitive approach that circumvents many of conventional methods' limitations. Lately, label-free applications with optical biosensors have been developed for short as well as for long RNAs. The low limits of detection at the pM level enabled by optical biosensors, together with a fast analysis, their reusability and the label-free scheme of operation, clearly highlight them among the most promising next-generation RNA screening platforms. This review covers the most relevant optical biosensor platforms and their potential for enabling sensitive and label-free RNA analysis.
Subject Medical Biotechnology Diagnostics (incl. Biosensors)
Keyword(s) Label-free detection
Microdevices
Optical biosensor
Plasmonics
RNA
DOI - identifier 10.1016/j.trac.2016.02.018
Copyright notice © 2016 Elsevier B.V. All rights reserved.
ISSN 0165-9936
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