Inflammation-induced sensitization of the brain in term infants

Fleiss, B, Tann, C, Degos, V, Sigaut, S, Van Steenwinckel, J, Schang, A, Kichev, A, Robertson, N, Mallard, C, Hagberg, H and Gressens, P 2015, 'Inflammation-induced sensitization of the brain in term infants', Developmental Medicine and Child Neurology, vol. 57, no. S3, pp. 17-28.


Document type: Journal Article
Collection: Journal Articles

Title Inflammation-induced sensitization of the brain in term infants
Author(s) Fleiss, B
Tann, C
Degos, V
Sigaut, S
Van Steenwinckel, J
Schang, A
Kichev, A
Robertson, N
Mallard, C
Hagberg, H
Gressens, P
Year 2015
Journal name Developmental Medicine and Child Neurology
Volume number 57
Issue number S3
Start page 17
End page 28
Total pages 12
Publisher Wiley-Blackwell
Abstract Perinatal insults are a leading cause of infant mortality and amongst survivors are frequently associated with neurocognitive impairment, cerebral palsy (CP), and seizure disorders. The events leading to perinatal brain injury are multifactorial. This review describes how one subinjurious factor affecting the brain sensitizes it to a second injurious factor, causing an exacerbated injurious cascade. We will review the clinical and experimental evidence, including observations of high rates of maternal and fetal infections in term-born infants with neonatal encephalopathy and cerebral palsy. In addition, we will discuss preclinical evidence for the sensitizing effects of inflammation on injuries, such as hypoxia-ischaemia, our current understanding of the mechanisms underpinning the sensitization process, and the possibility for neuroprotection.
Subject Neurology and Neuromuscular Diseases
Innate Immunity
Paediatrics
DOI - identifier 10.1111/dmcn.12723
Copyright notice © The Authors
ISSN 0012-1622
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