Direct oral anticoagulants and their clinical management

Dobie, G, O'Malley, C, Sze, M and Jackson, D 2017, 'Direct oral anticoagulants and their clinical management', Haematology and Transfusion International Journal, vol. 5, no. 5, pp. 1-4.


Document type: Journal Article
Collection: Journal Articles

Title Direct oral anticoagulants and their clinical management
Author(s) Dobie, G
O'Malley, C
Sze, M
Jackson, D
Year 2017
Journal name Haematology and Transfusion International Journal
Volume number 5
Issue number 5
Start page 1
End page 4
Total pages 4
Publisher Medcrave group
Abstract Thrombotic disorders are treated mostly with Heparin and Warfarin in cases requiring anticoagulation drugs. Due to limitations to these drugs including risk of bleeding and need for regular laboratory monitoring several Direct oral anticoagulants (DOACs) have been developed and shown to have more advantages than Warfarin. Nevertheless, these drugs are limited to use in some circumstances. As other anticoagulants, these drugs need to be managed and controlled to cope their over activities. Subsequently, many antidotes have been developed to reverse these DOACs. However, these antidotes are still understudies and need to be fully approved. The assessment of DOACs is developing and several drug-specific calibrators have been developed to measure DOACs activity in plasma.
Subject Haematology
Cardiovascular Medicine and Haematology not elsewhere classified
Keyword(s) Vitamin K antagonist
coronary artery
atrial fibrillation
heparin
warfarin
DOACs
Copyright notice © 2017 Authors
ISSN 2469-2778
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