Chinese Herbal Medicine for Functional Dyspepsia: Systematic Review of Systematic Reviews.

Chu, M, Wu, I, Ho, R, Wong, C, Zhang, A, Wu, J and Chung, V 2018, 'Chinese Herbal Medicine for Functional Dyspepsia: Systematic Review of Systematic Reviews.', Therapeutic Advances in Gastroenterology, vol. 11, pp. 1-24.

Document type: Journal Article
Collection: Journal Articles

Title Chinese Herbal Medicine for Functional Dyspepsia: Systematic Review of Systematic Reviews.
Author(s) Chu, M
Wu, I
Ho, R
Wong, C
Zhang, A
Wu, J
Chung, V
Year 2018
Journal name Therapeutic Advances in Gastroenterology
Volume number 11
Start page 1
End page 24
Total pages 24
Publisher Sage
Abstract Background: Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potential effectiveness and safety of CHM. Method: We conducted a comprehensive literature search for SRs with meta-analyses in eight international and Chinese databases. Pooled effect estimation from each meta-analysis was extracted. The AMSTAR instrument was used to assess the methodological quality of the included SRs. Results: A total of 14 SRs of mediocre quality assessing various CHMs, alone or in combination with conventional pharmacotherapy, were included. Meta-analyses showed that CHM was more effective than prokinetic agents for the alleviation of global dyspeptic symptoms. Three specific CHM formulae appeared to show superior results in the alleviation of global dyspeptic symptoms, including Si Ni San, modified Xiao Yao San and Xiang Sha Liu Jun Zi decoction. No significant difference in the occurrence of adverse events in using CHM or pharmacotherapy was reported. Conclusion: CHM can be considered as an alternative for the treatment of FD symptoms when prokinetic agents and proton pump inhibitors are contraindicated. Future trial design should focus on measuring changes in individual dyspeptic symptoms and differentiate the effectiveness of different CHM for postprandial distress syndrome and epigastric pain syndrome. A network meta-analysis approach should be used to explore the most promising CHM formula for FD treatment in the future.
Subject Traditional Chinese Medicine and Treatments
Keyword(s) functional dyspepsia
Chinese herbal medicine
Chinese herbs
proton pump inhibitors
systematic reviews
DOI - identifier 10.1177/1756284818785573
Copyright notice © The Author(s), 2018. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License
ISSN 1756-2848
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