Tunable silver-functionalized porous frameworks for antibacterial applications

Isaacs, M, Barbero, B, Durndell, L, Hilton, A, Olivi, L, Parlett, C, Wilson, K and Lee, A 2018, 'Tunable silver-functionalized porous frameworks for antibacterial applications', Antibiotics, vol. 7, no. 3, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

Title Tunable silver-functionalized porous frameworks for antibacterial applications
Author(s) Isaacs, M
Barbero, B
Durndell, L
Hilton, A
Olivi, L
Parlett, C
Wilson, K
Lee, A
Year 2018
Journal name Antibiotics
Volume number 7
Issue number 3
Start page 1
End page 13
Total pages 13
Publisher M D P I AG
Abstract Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2 CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2 CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).
Subject Biomaterials
Keyword(s) Antibacterial
Macroporous
Mesoporous
Silver
Surface functionalization
Titania
DOI - identifier 10.3390/antibiotics7030055
Copyright notice © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
ISSN 2079-6382
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