Correlations between intestinal innate immune genes and cecal microbiota highlight potential for probiotic development for immune modulation in poultry

Willson, N, Nattrass, G, Hughes, R, Moore, R, Stanley, D, Hynd, P and Forder, R 2018, 'Correlations between intestinal innate immune genes and cecal microbiota highlight potential for probiotic development for immune modulation in poultry', Applied Microbiology and Biotechnology, vol. 102, no. 21, pp. 9317-9329.


Document type: Journal Article
Collection: Journal Articles

Title Correlations between intestinal innate immune genes and cecal microbiota highlight potential for probiotic development for immune modulation in poultry
Author(s) Willson, N
Nattrass, G
Hughes, R
Moore, R
Stanley, D
Hynd, P
Forder, R
Year 2018
Journal name Applied Microbiology and Biotechnology
Volume number 102
Issue number 21
Start page 9317
End page 9329
Total pages 13
Publisher Springer
Abstract Immune function is influenced by the diversity and stability of the intestinal microbiota. A likely trade-off of immune function for growth has been demonstrated in heavier breeds of poultry that have been genetically selected for growth and feed efficiency traits. We investigated the expression of selected innate immune genes and genes encoding products involved in intestinal barrier function to determine whether function changes could be consistently linked to the phenotypic expression of feed conversion ratio (FCR), a common measure of performance within poultry broiler flocks. In addition, we compared individual cecal microbial composition with innate immune gene expression. Samples were utilised from two replicate trials termed P1E1 and P1E2. High (n = 12) and low (n = 12) performing birds were selected based on their individual FCR data from each replicate and combined for microbiota phylogenetic composition and immune gene expression analysis. Toll-like receptor 1 (TLR1La) and zonula occludens 1 (ZO1) were differentially expressed between high- and low-performing broilers. Several taxa were correlated with FCR; of these, unclassified YS2 and ZO1 were also positively correlated with each other. Interactions between taxa and differentially expressed innate immune genes between P1E1 and P1E2 were much greater compared to relationships between high- and low-performing birds. At the level of phylum, reciprocal correlations between tight junction proteins and Toll-like receptors with Bacteroidetes and Firmicutes were evident, as were correlations at the genus level.
Subject Bacteriology
Innate Immunity
Keyword(s) Broiler
Feed conversion ratio
Innate immunity
Microbiota
DOI - identifier 10.1007/s00253-018-9281-1
Copyright notice © Springer-Verlag GmbH Germany, part of Springer Nature 2018
ISSN 0175-7598
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