Toxicity study of isolated polypeptide from wool hydrolysate

Li, J, Li, Y, Zhang, Y, Liu, X, Zhao, Z, Zhang, J, Han, Y and Zhou, D 2013, 'Toxicity study of isolated polypeptide from wool hydrolysate', Food and Chemical Toxicology, vol. 57, pp. 338-345.

Document type: Journal Article
Collection: Journal Articles

Title Toxicity study of isolated polypeptide from wool hydrolysate
Author(s) Li, J
Li, Y
Zhang, Y
Liu, X
Zhao, Z
Zhang, J
Han, Y
Zhou, D
Year 2013
Journal name Food and Chemical Toxicology
Volume number 57
Start page 338
End page 345
Total pages 8
Publisher Elsevier
Abstract The cytotoxicity of wool polypeptide has been evaluated by both cell and animal models. Wool was dissolved in sodium hydroxide solution, the pH value of the solution was adjusted to 5.55 and the precipitate was harvested as wool polypeptide. The spray-dried polypeptide was collected as powders and characterized by SEM, FTIR and TG-DSC. The cell culturing results showed that wool polypeptide had no obvious negative effect on cell viability in vitro. Both acute oral toxicity and subacute 30-day oral toxicology studies showed that wool polypeptide had no influence on body weight, feed consumption, blood chemistry, and hematology at any dose levels. There were no treatment related findings on gross or detailed necroscopy, organ weights, organ/body weight ratios and histology. Our study indicated the absence of toxicity in wool polypeptide and supported its safe use as a food ingredient or drug carrier.
Subject Biomaterials
Keyword(s) Acute toxicity
Food safety
Subacute toxicity
Wool polypeptide
DOI - identifier 10.1016/j.fct.2013.03.047
Copyright notice © 2013 Elsevier Ltd. All rights reserved.
ISSN 0278-6915
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