Transmission Near-Field Scanning Optical Microscopy Investigation on Cellular Uptake Behavior of Iron Oxide Nanoparticles

Zhang, Y, Kyle, J, Penchev, M, Yazdanpanah, V, Yu, J, Li, Y, Yang, M, Budak, G, Ozbay, E, Ozkan, M and Ozkan, C 2012, 'Transmission Near-Field Scanning Optical Microscopy Investigation on Cellular Uptake Behavior of Iron Oxide Nanoparticles', BioNanoScience, vol. 2, no. 3, pp. 135-143.


Document type: Journal Article
Collection: Journal Articles

Title Transmission Near-Field Scanning Optical Microscopy Investigation on Cellular Uptake Behavior of Iron Oxide Nanoparticles
Author(s) Zhang, Y
Kyle, J
Penchev, M
Yazdanpanah, V
Yu, J
Li, Y
Yang, M
Budak, G
Ozbay, E
Ozkan, M
Ozkan, C
Year 2012
Journal name BioNanoScience
Volume number 2
Issue number 3
Start page 135
End page 143
Total pages 9
Publisher Springer
Abstract Cellular uptake behavior of iron oxide nanoparticles is investigated using a transmission near-field scanning optical microscopy (NSOM) without the need of fluorescent labeling. By using the transmission NSOM system, we could simultaneously explore the near-field optical analysis of the cell interior and record the topographic information of the cell surface. The cell endocytosis of iron oxide nanoparticles by normal breast MCF10A cells is first studied by this transmission NSOM system, and this dual functional nanoscale-resolution microscopy shows the capability of mapping the spatial localization of nanoparticles in/outside cell surface without the need of fluorescence labeling. Nanoscale optical signature patterns for iron oxide nanoparticle-loaded vesicles inside the cells were observed and analyzed.
Subject Biomedical Instrumentation
Keyword(s) AFM
Endocytosis
Iron oxide
MCF10A
Nanoparticle
NSOM
DOI - identifier 10.1007/s12668-012-0043-8
Copyright notice © Springer Science+Business Media, LLC 2012.
ISSN 2191-1630
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