A nanoporous membrane based impedance sensing platform for DNAsensing with gold nanoparticle amplification

Ye, W, Shi, J, Chan, C, Zhang, Y and Yang, M 2014, 'A nanoporous membrane based impedance sensing platform for DNAsensing with gold nanoparticle amplification', Sensors and Actuators, B: Chemical, vol. 193, pp. 877-882.


Document type: Journal Article
Collection: Journal Articles

Title A nanoporous membrane based impedance sensing platform for DNAsensing with gold nanoparticle amplification
Author(s) Ye, W
Shi, J
Chan, C
Zhang, Y
Yang, M
Year 2014
Journal name Sensors and Actuators, B: Chemical
Volume number 193
Start page 877
End page 882
Total pages 6
Publisher Elsevier
Abstract Nucleic acids based detection has become increasingly important for biomedical diagnostics, environ-mental monitoring and food screening. In this paper, a nanoporous alumina membrane based impedancesensing platform with gold nanoparticle tags amplification was developed for DNA sensing. Singlestranded DNA (ssDNA) probes were first covalently immobilized in nanopore walls via chemical link-ers. DNA hybridization in the nanopores induced blockage in the nanopores, which could be detected byelectrochemical impedance spectroscopy (EIS). The blockage signal could be further amplified by goldnanoparticles (AuNPs) conjugation and silver catalytic deposition method to reach a limit of detection(LOD) of 50 pM. This platform is promising for simple, rapid and sensitive DNA detection
Subject Biomedical Instrumentation
Keyword(s) DNA sensor
Gold nanoparticles
Nanoporous alumina membrane
Silver enhancement
DOI - identifier 10.1016/j.snb.2013.09.115
Copyright notice © 2013 Elsevier B.V. All rights reserved.
ISSN 0925-4005
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