Fabrication of silk fibroin nanoparticles for controlled drug delivery

Zhao, Z, Chen, A, Li, Y, Hu, J, Liu, X, Li, J, Zhang, Y, Li, G and Zheng, Z 2012, 'Fabrication of silk fibroin nanoparticles for controlled drug delivery', Journal of Nanoparticle Research, vol. 14, no. 4, pp. 1-1.


Document type: Journal Article
Collection: Journal Articles

Title Fabrication of silk fibroin nanoparticles for controlled drug delivery
Author(s) Zhao, Z
Chen, A
Li, Y
Hu, J
Liu, X
Li, J
Zhang, Y
Li, G
Zheng, Z
Year 2012
Journal name Journal of Nanoparticle Research
Volume number 14
Issue number 4
Start page 1
End page 1
Total pages 1
Publisher Springer
Abstract A novel solution-enhanced dispersion by supercritical CO2 (SEDS) was employed to prepare silk fibroin (SF) nanoparticles. The resulting SF nanoparticles exhibited a good spherical shape, a smooth surface, and a narrow particle size distribution with a mean particle diameter of about 50 nm. The results of X-ray powder diffraction, thermo gravimetry-differential scanning calorimetry, and Fourier transform infrared spectroscopy analysis of the SF nanoparticles before and after ethanol treatment indicated conformation transition of SF nanoparticles from random coil to β-sheet form and thus water insolubility. The MTS assay also suggested that the SF nanoparticles after ethanol treatment imposed no toxicity. A non-steroidal anti-inflammatory drug, indomethacin (IDMC), was chosen as the model drug and was encapsulated in SF nanoparticles by the SEDS process. The resulting IDMCSF nanoparticles, after ethanol treatment, possessed a theoretical average drug load of 20%, an actual drug load of 2.05%, and an encapsulation efficiency of 10.23%. In vitro IDMC release from the IDMCSF nanoparticles after ethanol treatment showed a significantly sustained release over 2 days. These studies of SF nanoparticles indicated the suitability of the SF nanoparticles prepared by the SEDS process as a biocompatible carrier to deliver drugs and also the feasibility of using the SEDS process to reach the goal of co-precipitation of drug and SF as composite nanoparticles for controlled drug delivery.
Subject Biomaterials
Keyword(s) Drug delivery
Indomethacin
Nanoparticles
Silk fibroin
Supercritical CO 2
DOI - identifier 10.1007/s11051-012-0736-5
Copyright notice © Springer Science+Business Media B.V. 2012
ISSN 1388-0764
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