High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Boutet, S, Lomb, L, Williams, G, et al, and Martin, A 2012, 'High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography', Science, vol. 337, no. 6092, pp. 362-364.


Document type: Journal Article
Collection: Journal Articles

Title High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
Author(s) Boutet, S
Lomb, L
Williams, G
et al,
Martin, A
Year 2012
Journal name Science
Volume number 337
Issue number 6092
Start page 362
End page 364
Total pages 3
Publisher American Association for the Advancement of Science (A A A S)
Abstract Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.
Subject Condensed Matter Imaging
DOI - identifier 10.1126/science.1217737
Copyright notice ©
ISSN 0036-8075
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