Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH

Tomanin, P, Cherepanov, P, Besford, Q, Christofferson, A, Amodio, A, McConville, C, Yarovsky, I, Caruso, F and Cavalieri, F 2018, 'Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH', ACS Applies Materials & Interfaces, vol. 10, no. 49, pp. 42786-42795.

Document type: Journal Article
Collection: Journal Articles

Title Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH
Author(s) Tomanin, P
Cherepanov, P
Besford, Q
Christofferson, A
Amodio, A
McConville, C
Yarovsky, I
Caruso, F
Cavalieri, F
Year 2018
Journal name ACS Applies Materials & Interfaces
Volume number 10
Issue number 49
Start page 42786
End page 42795
Total pages 10
Publisher American Chemical Society
Abstract Nanostructured materials have great potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesis of electrocatalytically active cobalt phosphate nanostructures (CPNs) using a simple, low-cost, and scalable preparation method. The electrocatalytic properties of the CPNs toward the electrooxidation of glucose (Glu) were studied by cyclic voltammetry and chronoamperometry in relevant biological electrolytes, such as phosphate-buffered saline (PBS), at physiological pH (7.4). Using the CPNs, Glu detection could be achieved over a wide range of biologically relevant concentrations, from 1 to 30 mM Glu in PBS, with a sensitivity of 7.90 nA/mM cm2 and a limit of detection of 0.3 mM, thus fulfilling the necessary requirements for human blood Glu detection. In addition, the CPNs showed a high structural and functional stability over time at physiological pH. The CPN-coated electrodes could also be used for Glu detection in the presence of interfering agents (e.g., ascorbic acid and dopamine) and in human serum. Density functional theory calculations were performed to evaluate the interaction of Glu with different faceted cobalt phosphate surfaces; the results revealed that specific surface presentations of under-coordinated cobalt led to the strongest interaction with Glu, suggesting that enhanced detection of Glu by the CPNs can be achieved by lowering the surface coordination of cobalt. Our results highlight the potential use of phosphate-based nanostructures as catalysts for electrochemical sensing of biochemical analytes.
Subject Theoretical and Computational Chemistry not elsewhere classified
Keyword(s) Cobalt phosphate
Density functional theory
Glucose sensing
DOI - identifier 10.1021/acsami.8b12966
Copyright notice © 2018 American Chemical Society
ISSN 1944-8244
NHMRC Grant ID 1135806
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