Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

Barty, A, Caleman, C, Aquila, A, et al, and Martin, A 2012, 'Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements', Nature Photonics, vol. 6, no. 1, pp. 35-40.


Document type: Journal Article
Collection: Journal Articles

Title Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements
Author(s) Barty, A
Caleman, C
Aquila, A
et al,
Martin, A
Year 2012
Journal name Nature Photonics
Volume number 6
Issue number 1
Start page 35
End page 40
Total pages 6
Publisher Nature Publishing Group
Abstract X-ray free-electron lasers have enabled new approaches to the structural determination of protein crystals that are too small or radiation-sensitive for conventional analysis. For sufficiently short pulses, diffraction is collected before significant changes occur to the sample, and it has been predicted that pulses as short as 10 fs may be required to acquire atomic-resolution structural information. Here, we describe a mechanism unique to ultrafast, ultra-intense X-ray experiments that allows structural information to be collected from crystalline samples using high radiation doses without the requirement for the pulse to terminate before the onset of sample damage. Instead, the diffracted X-rays are gated by a rapid loss of crystalline periodicity, producing apparent pulse lengths significantly shorter than the duration of the incident pulse. The shortest apparent pulse lengths occur at the highest resolution, and our measurements indicate that current X-ray free-electron laser technology should enable structural determination from submicrometre protein crystals with atomic resolution.
Subject Condensed Matter Imaging
DOI - identifier 10.1038/nphoton.2011.297
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ISSN 1749-4885
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