Caging of planktonic rotifers in microfluidic environment for sub-lethal aquatic toxicity tests

Cartlidge, R and Wlodkowic, D 2018, 'Caging of planktonic rotifers in microfluidic environment for sub-lethal aquatic toxicity tests', Biomicrofluidics, vol. 12, no. 4, pp. 1-11.


Document type: Journal Article
Collection: Journal Articles

Title Caging of planktonic rotifers in microfluidic environment for sub-lethal aquatic toxicity tests
Author(s) Cartlidge, R
Wlodkowic, D
Year 2018
Journal name Biomicrofluidics
Volume number 12
Issue number 4
Start page 1
End page 11
Total pages 11
Publisher A I P Publishing LLC
Abstract Quantification of neuro-behavioural responses of intact small model organisms has been proposed as a sensitive, sub-lethal alternative to conventional toxicity testing. Such bioassays are characterized by a high physiological and ecological relevance, short response times, increased sensitivity, and non-invasive nature. Despite a significant potential for predictive aquatic toxicology analysis of behavioural traits of micro-invertebrates in microfluidic environment has received little attention. In this work, we demonstrate a new Lab-on-a-Chip technology capable of effectively caging freshwater rotifers Brachionus calyciflorus for real-time video-microscopy analysis. We demonstrate that behavioural bioassays performed under microfluidic perfusion can significantly enhance the sensitivity of conventional ecotoxicology test protocols.
Subject Environmental Impact Assessment
Animal Behaviour
Animal Neurobiology
DOI - identifier 10.1063/1.5042779
Copyright notice © 2018 Author(s).
ISSN 1932-1058
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