Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

Arnlund, D, Johansson, L, Wickstrand, C and Martin, A 2014, 'Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser', Nature Methods, vol. 11, no. 9, pp. 923-926.


Document type: Journal Article
Collection: Journal Articles

Title Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser
Author(s) Arnlund, D
Johansson, L
Wickstrand, C
Martin, A
Year 2014
Journal name Nature Methods
Volume number 11
Issue number 9
Start page 923
End page 926
Total pages 4
Publisher Nature Publishing Group
Abstract We describe a method to measure ultrafast protein structural changes using time-resolved wide-angle X-ray scattering at an X-ray free-electron laser. We demonstrated this approach using multiphoton excitation of the Blastochloris viridis photosynthetic reaction center, observing an ultrafast global conformational change that arises within picoseconds and precedes the propagation of heat through the protein. This provides direct structural evidence for a 'protein quake': the hypothesis that proteins rapidly dissipate energy through quake-like structural motions.
Subject Condensed Matter Imaging
DOI - identifier 10.1038/nmeth.3067
Copyright notice © 2014 Nature America, Inc. All rights reserved.
ISSN 1548-7091
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