Nanostructured biomedical selenium at the biological interface

Ching Tan, V, Hinchman, A, Williams, R, Tran, P and Fox, K 2018, 'Nanostructured biomedical selenium at the biological interface', Biointerphases, vol. 13, no. 6, pp. 1-19.


Document type: Journal Article
Collection: Journal Articles

Title Nanostructured biomedical selenium at the biological interface
Author(s) Ching Tan, V
Hinchman, A
Williams, R
Tran, P
Fox, K
Year 2018
Journal name Biointerphases
Volume number 13
Issue number 6
Start page 1
End page 19
Total pages 19
Publisher A I P Publishing LLC
Abstract This paper critically reviews the current evidence of research in biomedical applications of selenium nanoparticles (SeNPs) and their effects at cellular and tissue levels. In recent years, interest in SeNPs as a natural trace element nanomaterial for nanomedicine has resulted in a number of studies evaluating their bioactivities, such as anticancer, antimicrobial, and antioxidant properties. Significant data have been generated to demonstrate the effectiveness of SeNPs alone or in combination with other reagents. Their activities are demonstrated through in vitro and in vivo experimentation; yet, the levels of efficacy need to be improved, particularly when compared with those of pharmaceutical drugs (such as antibiotics and cytotoxic chemotherapeutic drugs). However, promising evidence suggests decreased toxicity when using SeNPs, and more importantly their ability to perform as an interfacing biomaterial with cells and tissues. SeNPs have demonstrated unique antibacterial properties: they inhibit bacterial adhesion, growth, and/or quorum sensing and as a result prevent biofilm formation on medical devices, to name a few. Therefore, as with other nanomaterials, SeNPs warrant further study as part of the biomaterial-based therapeutic toolkit as an alternative to traditional pharmaceutical agents. This paper will provide a succinct review of recent studies on SeNPs to critically assess the findings in the light of effectiveness, particularly highlighting the roles of the cellular interface. Finally, an outlook of the potential of SeNPs will be presented to highlight the need for more intensive studies of material stability, mechanistic understanding at subcellular levels, and investigations into their combinational and/or synergistic effects with other bioactive reagents including pharmaceutical drugs.
Subject Medical Devices
Biomaterials
DOI - identifier 10.1116/1.5042693
Copyright notice © Author(s) 2018. Creative Commons Attribution (CC BY) license.
ISSN 1559-4106
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