Flexible MoS2‐Embedded Human Serum Albumin Hollow Nanocapsules with Long Circulation Times and High Targeting Ability for Efficient Tumor Ablation

Xu, C, Teng, Z, Zhang, Y, Yuwen, L and Bao, L 2018, 'Flexible MoS2‐Embedded Human Serum Albumin Hollow Nanocapsules with Long Circulation Times and High Targeting Ability for Efficient Tumor Ablation', Advanced Functional Materials, vol. 28, 1804081, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title Flexible MoS2‐Embedded Human Serum Albumin Hollow Nanocapsules with Long Circulation Times and High Targeting Ability for Efficient Tumor Ablation
Author(s) Xu, C
Teng, Z
Zhang, Y
Yuwen, L
Bao, L
Year 2018
Journal name Advanced Functional Materials
Volume number 28
Article Number 1804081
Start page 1
End page 8
Total pages 8
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract Herein, MoS2‐embedded human serum albumin hollow nanocapsules (denoted MoS2/HSA) are successfully prepared via a hard‐core‐assisted layer‐by‐layer coating approach. The hollow MoS2/HSA nanocapsules possess an uniform size (280 nm), a larger hollow cavity, a low Young's modulus (222 ± 20 MPa), excellent photothermal conversion ability, and a high drug loading capacity for doxorubicin (27 wt%). The flexible hollow MoS2/HSA nanocapsules exhibit significantly enhanced cellular uptake efficiency against breast cancer cells duo to their flexible property and targeting ability of HSA. In vivo experiments show that the flexible MoS2/HSA could reduce phagocytosis and effectively improve blood persistence and tumor accumulation. In vitro and in vivo experiments have demonstrated that the flexible MoS2/HSA based nanoplatforms effectively ablate breast cancer cells via synergistic photothermal and chemical therapy.
Subject Nanomaterials
Keyword(s) Flexible nanoplatform
High targeting
Human serum albumin
Long circulation time
Tumor treatment
DOI - identifier 10.1002/adfm.201804081
Copyright notice © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1616-301X
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