Preparation and Characterization of Paclitaxel Loaded SF/PLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2

Zhao, Z, Li, Y and Zhang, Y 2015, 'Preparation and Characterization of Paclitaxel Loaded SF/PLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2', Journal of Nanomaterials, vol. 2015, pp. 1-7.


Document type: Journal Article
Collection: Journal Articles

Title Preparation and Characterization of Paclitaxel Loaded SF/PLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2
Author(s) Zhao, Z
Li, Y
Zhang, Y
Year 2015
Journal name Journal of Nanomaterials
Volume number 2015
Start page 1
End page 7
Total pages 7
Publisher Hindawi
Abstract Paclitaxel loaded silk fibroin/PLLA-PEG-PLLA (PTX-SF/PLLA-PEG-PLLA) nanoparticles with a mean particle size of about 651 nm were fabricated successfully by the SEDS process. Fourier transform infrared (FTIR) spectroscopy analysis indicated that the PTX was encapsulated by SF/PLLA-PEG-PLLA nanoparticles. X-ray powder diffraction (XRPD) analysis supported the results of FTIR analysis and also suggested that the crystalline state of PTX was decreased obviously. Furthermore, the UV-Vis/HPLC analysis showed that drug load (DL) and encapsulation efficiency (EE) were 18.1% and 90.2%, respectively. The in vitro drug release experiment suggested that the PTX-SF/PLLA-PEG-PLLA nanoparticles exhibited a sustained release and only 16.1% and 24.5% of paclitaxel were released at pH 7.4 and 6.0, respectively, in one week. The PTX-SF/PLLA-PEG-PLLA nanoparticles drug delivery system with pH-dependent release property has potential application in the field of tumor therapy.
Subject Biomaterials
Keyword(s) Silk Fibroin Nanoparticles
Targeted Drug-Delivery
Poly(L-Lactic Acid)
Block-Copolymer
Cancer-Therapy
In-Vitro
Microspheres
Release
Microparticles
Fabrication
DOI - identifier 10.1155/2015/913254
Copyright notice Copyright © 2015 Zheng Zhao et al. This is an open access article distributed under the Creative Commons Attribution License
ISSN 1687-4110
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