Advances in functionalized polymer coatings on biodegradable magnesium alloys - A review

Li, L, Cui, L, Zeng, R, Li, S, Chen, X, Cheng, Y and Mathan, B 2018, 'Advances in functionalized polymer coatings on biodegradable magnesium alloys - A review', Acta Biomaterialia, vol. 79, pp. 23-36.


Document type: Journal Article
Collection: Journal Articles

Title Advances in functionalized polymer coatings on biodegradable magnesium alloys - A review
Author(s) Li, L
Cui, L
Zeng, R
Li, S
Chen, X
Cheng, Y
Mathan, B
Year 2018
Journal name Acta Biomaterialia
Volume number 79
Start page 23
End page 36
Total pages 14
Publisher Elsevier BV
Abstract Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and excellent biomechanical compatibility. However, their high degradation rate in the physiological environment should be well tackled prior to clinical applications. This review summarizes the latest progress in the development of polymeric coatings on biodegradable Mg alloys over the last decade, regarding preparation strategies for polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), polydopamine (PDA), chitosan (CS), collagen (Col) and their composite, and their performance in terms of corrosion resistance and biocompatibility. Feasible perspectives and developing directions of next generation of polymeric coatings with respect to biomedical Mg alloys are briefly discussed. Statement of Significance: Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and suitable biomechanical compatibility. However, the principal drawback of Mg-based implants is their poor corrosion resistance in physiological environments. Hence, it is vital to mitigate the degradation/corrosion behavior of Mg alloys for safe biomedical deployments. This review summarizes the latest progress in development of polymeric coatings on biomedical Mg alloys regarding preparation strategy, corrosion resistance and biocompatibility, including polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), chitosan (CS), polydopamine (PDA), collagen (Col) and their composite. In addition, functionalized polymer coatings with Mg alloys exhibits a promising prospect owing to their ability of degradation along with biocompatibility, self-healing, drug-delivery and osteoinduction.
Subject Metals and Alloy Materials
Polymers and Plastics
Keyword(s) Biomaterial
Degradation
Functional properties
Magnesium alloy
Polymer coating
DOI - identifier 10.1016/j.actbio.2018.08.030
Copyright notice © 2018 Acta Materialia Inc.
ISSN 1742-7061
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