The extraction of single-particle diffraction patterns from a multiple-particle diffraction pattern

Martin, A, Morgan, A, Ekeberg, T, Loh, D, Maia, F, Wang, F, Spence, J and Chapman, H 2013, 'The extraction of single-particle diffraction patterns from a multiple-particle diffraction pattern', Optics Express, vol. 21, no. 13, pp. 15102-15112.


Document type: Journal Article
Collection: Journal Articles

Title The extraction of single-particle diffraction patterns from a multiple-particle diffraction pattern
Author(s) Martin, A
Morgan, A
Ekeberg, T
Loh, D
Maia, F
Wang, F
Spence, J
Chapman, H
Year 2013
Journal name Optics Express
Volume number 21
Issue number 13
Start page 15102
End page 15112
Total pages 11
Publisher Optical Society of America
Abstract The structures of biological molecules may soon be determined with X-ray free-electron lasers without crystallization by recording the coherent diffraction patterns of many identical copies of a molecule. Most analysis methods require a measurement of each molecule individually. However, current injection methods deliver particles to the X-ray beam stochastically and the maximum yield of single particle measurements is 37% at optimal concentration. The remaining 63% of pulses intercept no particles or multiple particles. We demonstrate that in the latter case single particle diffraction patterns can be extracted provided the particles are sufficiently separated. The technique has the potential to greatly increase the amount of data available for three-dimensional imaging of identical particles with X-ray lasers.
Subject Condensed Matter Imaging
DOI - identifier 10.1364/OE.21.015102
Copyright notice © 2013 Optical Society of America.
ISSN 1094-4087
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Altmetric details:
Access Statistics: 11 Abstract Views  -  Detailed Statistics
Created: Thu, 31 Jan 2019, 11:26:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us