Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria

Salwati, E, Minigo, G, Woodberry, T, Piera, K, deSilva, H, Kenangalem, E, Tjitra, E, Coppel, R, Price, R, Anstey, N and Plebanski, M 2011, 'Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria', Journal of Infectious Diseases, vol. 203, no. 8, pp. 1192-1199.


Document type: Journal Article
Collection: Journal Articles

Title Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria
Author(s) Salwati, E
Minigo, G
Woodberry, T
Piera, K
deSilva, H
Kenangalem, E
Tjitra, E
Coppel, R
Price, R
Anstey, N
Plebanski, M
Year 2011
Journal name Journal of Infectious Diseases
Volume number 203
Issue number 8
Start page 1192
End page 1199
Total pages 8
Publisher Oxford University Press
Abstract Background. Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. Methods. Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n = 34), and vivax malaria (n = 12) or asymptomatic residents (n = 10) of Papua, Indonesia. Responses were reassessed 728 days following treatment. Results. The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γsecreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. Conclusion. Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection.
Subject Immunology not elsewhere classified
DOI - identifier 10.1093/infdis/jiq166
Copyright notice © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
ISSN 0022-1899
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